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(SA) Succinylacetone-d6

目录号 数量 价格 提前通知时间
4337-500ug 0.50 mg $259 12 天
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Succinylacetone is a product of tyrosine catabolism and an inhibitor of heme biosynthesis. Succinylacetone (SA) testing in dried neonatal blood spots, followed by quantitation of SA in blood or urine in high-risk neonates, has excellent sensitivity and specificity for the diagnosis of tyrosinemia type 1 [1]. Succinylacetone also serves as a tool for studying the defects of heme synthesis on cellular processes.

[1] Kehar M., Sen Sarma M., Seetharaman J., Jimenez Rivera C., Chakraborty P. Decoding hepatorenal tyrosinemia type 1: Unraveling the impact of early detection, NTBC, and the role of liver transplantation. Can Liver J. 2024. 7(1). P.54-63.

General properties

Appearance: white solid
Molecular weight: 160.21
Molecular formula: C7H4D6N2O2
Solubility: in water
Quality control: NMR 1H and HPLC-MS (95+ %, D: 98+ %)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
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