Activated esters (bifunctional)
Primary or secondary amino groups are ubiquitous in biomolecules. They are present in proteins and peptides as ε-amino groups of lysines and N-terminal amino groups. Many natural and synthetic small molecules are amines, and DNAs with amino groups can be prepared by solid phase synthesis, and enzymatically.
Amino groups can be modified by acylation with various activated carbonyl compounds. Among these compounds, activated N-hydroxysuccinimide esters are most suitable for biolabeling and bioconjugation applications.
Compared to other activated esters, NHS derivatives possess good stability in aqueous environment. Optimal pH for the coupling of amines with NHS esters in aqueous buffers is 8.3-8.5. Labeling is also possible in organic solvents. Polar aprotic solents, such as DMF or DMSO, are preferred. One equivalent of tertiary amine base, such as triethylamine, or diisopropylethylamine (DIPEA) is necessary to achieve efficient amine acylation in non-aqueous solution.
3-马来酰亚胺丙酸NHS-酯 (3-Maleimidopropionic acid NHS-ester)
具有胺反应性琥珀酰亚胺酯和巯基反应性的马来酰亚胺基团的双功能交联剂。| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 3419-100mg | 100 mg | – | 现货 | |
| 3419-500mg | 500 mg | $110 | 现货 |
Alkyne-PEG2-NHS ester
Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on diethyleneglycol (PEG2).| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 2219-1g | 1 g |
$450
|
现货 | |
| 2219-5g | 5 g |
$980
|
现货 |
Alkyne-PEG3-NHS ester
Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on triethyleneglycol (PEG3).| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 2298-1g | 1 g |
$490
|
现货 | |
| 2298-5g | 5 g |
$980
|
现货 |
Alkyne-PEG4-NHS ester
Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on tetraethyleneglycol (PEG4).| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 2409-100mg | 100 mg | $250 | 现货 | |
| 2409-1g | 1 g |
$790
|
现货 |
Azide-PEG6-NHS ester
A hydrophilic bifunctional linker with azide and NHS ester function groups flanking PEG6 (hexaethylene glycol).| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 3692-250mg | 250 mg | $325 | 现货 | |
| 3692-1g | 1 g |
$539
|
现货 |
Azidobutyric acid NHS ester
Activated NHS ester for azido-labeling of peptides and proteins.| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 53720 | 50 mg | $110 | 现货 | |
| 63720 | 100 mg | $210 | 现货 | |
| 73720 | 1 g |
$950
|
现货 | |
| 83720 | 5 g | 请查询 | 现货 |
Biotin-PEG4-NHS ester
PEG4-containing activated ester for simple and efficient biotin labeling of antibodies, proteins, and other primary amine-containing biomolecules.| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 2893-100mg | 100 mg | $145 | 现货 | |
| 2893-1g | 1 g |
$590
|
现货 |
DBCO NHS 酯
偶氮二苯并环辛炔 (DBCO、ADIBO) 试剂用于应变促进的无铜点击化学 (SPAAC)。该试剂含有 NHS 酯官能团，用于将环辛炔连接到各种分子上。| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 34720 | 10 mg | $80 | 现货 | |
| 44720 | 25 mg | $110 | 现货 | |
| 54720 | 50 mg | $135 | 现货 | |
| 64720 | 100 mg | $210 | 现货 | |
| 94720 | 1 g |
$1000
|
现货 | |
| K4720 | 5 g |
$3570
|
现货 |
DBCO-PEG6-NHS ester
A heterobifunctional linker with DBCO and NHS ester function groups flanking PEG6 (hexaethylene glycol).| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 3664-10mg | 10 mg | – | 现货 | |
| 3664-50mg | 50 mg | $247 | 现货 | |
| 3664-100mg | 100 mg |
$449
|
现货 | |
| 3664-1g | 1 g |
$3490
|
5 天 |
DBCO STP酯 (DBCO STP ester)
一种活化酯用于蛋白质/抗体/肽的修饰，引入到无铜点击化学反应。| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 2584-5mg | 5 mg | – | 5 天 | |
| 2584-10mg | 10 mg | $90 | 5 天 | |
| 2584-25mg | 25 mg | $180 | 现货 | |
| 2584-100mg | 100 mg |
$450
|
5 天 | |
| 2584-500mg | 500 mg |
$1700
|
现货 | |
| 2584-1g | 1 g |
$3000
|
现货 | |
| 2584-5g | 5 g | 请查询 | 现货 |
Disuccinimidyl glutarate (DSG)
Homobifunctional crosslinker with two NHS ester groups at each end of a short 5-atom (7.7 angstrom) spacer.| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 4018-100mg | 100 mg | $95 | 现货 | |
| 4018-1g | 1 g |
$410
|
现货 |
Exo-BCN-PNP
BCN-PNP carbonate is a tool to introduce BCN moety via carbamate linkage with primary amino groups of substrate.| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 4043-100mg | 100 mg | $280 | 现货 | |
| 4043-500mg | 500 mg |
$990
|
现货 |
Hexynoic acid NHS ester
Hexynoic acid NHS ester for the labeling of biomolecules with alkyne group for copper-catalyzed click chemistry.| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 41720 | 25 mg | $95 | 现货 | |
| 51720 | 50 mg | $180 | 现货 | |
| 61720 | 100 mg | $290 | 现货 | |
| 91720 | 1 g | 请查询 | 现货 |
Hexynoic acid STP ester
Alkyne activated ester for the modification of amine groups. STP ester group is an excellent alternative to NHS ester functionality.| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 569-25mg | 25 mg | $95 | 现货 | |
| 569-100mg | 100 mg | $185 | 现货 | |
| 569-500mg | 500 mg |
$850
|
现货 |
戊烯酸STP酯 (Pentynoic acid STP ester)
一种活化酯，用于将炔基引入肽/蛋白质和链接反应。| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 30720 | 10 mg | $110 | 5 天 | |
| 40720 | 25 mg | $210 | 现货 | |
| 50720 | 50 mg |
$410
|
现货 | |
| 60720 | 100 mg |
$595
|
5 天 |
TCO-PEG4-NHS ester (axial isomer)
A heterobifunctional linker with trans-cyclooctene and NHS ester groups flanking PEG4 (tetraethylene glycol) for labeling of antibodies, proteins, and other primary amine-containing biomolecules.| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 3056-10mg | 10 mg | $145 | 现货 | |
| 3056-25mg | 25 mg | $225 | 现货 | |
| 3056-100mg | 100 mg |
$550
|
现货 |
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