Activated esters (bifunctional)

Primary or secondary amino groups are ubiquitous in biomolecules. They are present in proteins and peptides as ε-amino groups of lysines and N-terminal amino groups. Many natural and synthetic small molecules are amines, and DNAs with amino groups can be prepared by solid phase synthesis, and enzymatically.

Amino groups can be modified by acylation with various activated carbonyl compounds. Among these compounds, activated N-hydroxysuccinimide esters are most suitable for biolabeling and bioconjugation applications.

NHS ester coupling chemistry

Compared to other activated esters, NHS derivatives possess good stability in aqueous environment. Optimal pH for the coupling of amines with NHS esters in aqueous buffers is 8.3-8.5. Labeling is also possible in organic solvents. Polar aprotic solents, such as DMF or DMSO, are preferred. One equivalent of tertiary amine base, such as triethylamine, or diisopropylethylamine (DIPEA) is necessary to achieve efficient amine acylation in non-aqueous solution.

3-马来酰亚胺丙酸NHS-酯 (3-Maleimidopropionic acid NHS-ester)

具有胺反应性琥珀酰亚胺酯和巯基反应性的马来酰亚胺基团的双功能交联剂。
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目录号 数量 价格 提前通知时间
3419-100mg 100 mg –   现货
3419-500mg 500 mg $110 现货
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Alkyne-PEG2-NHS ester

Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on diethyleneglycol (PEG2).
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目录号 数量 价格 提前通知时间
2219-1g 1 g $450 现货
2219-5g 5 g $980 现货
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Alkyne-PEG3-NHS ester

Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on triethyleneglycol (PEG3).
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目录号 数量 价格 提前通知时间
2298-1g 1 g $490 现货
2298-5g 5 g $980 现货
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Alkyne-PEG4-NHS ester

Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on tetraethyleneglycol (PEG4).
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目录号 数量 价格 提前通知时间
2409-100mg 100 mg $250 现货
2409-1g 1 g $790 现货
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Azide-PEG6-NHS ester

A hydrophilic bifunctional linker with azide and NHS ester function groups flanking PEG6 (hexaethylene glycol).
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目录号 数量 价格 提前通知时间
3692-250mg 250 mg $325 现货
3692-1g 1 g $539 现货
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Azidobutyric acid NHS ester

Activated NHS ester for azido-labeling of peptides and proteins.
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目录号 数量 价格 提前通知时间
53720 50 mg $110 现货
63720 100 mg $210 现货
73720 1 g $950 现货
83720 5 g 请查询 现货
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Biotin-PEG4-NHS ester

PEG4-containing activated ester for simple and efficient biotin labeling of antibodies, proteins, and other primary amine-containing biomolecules.
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目录号 数量 价格 提前通知时间
2893-100mg 100 mg $145 现货
2893-1g 1 g $590 现货
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Biotin-XX-NHS ester

Biotin derivative with long spacer to reduce steric effect when binding amino acids, peptides, or proteins by reacting with primary amines.
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目录号 数量 价格 提前通知时间
2897-100mg 100 mg $225 现货
2897-1g 1 g $670 现货
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DBCO-NHS 酯

偶氮二苯并环辛炔 (DBCO、ADIBO) 试剂用于应变促进的无铜点击化学 (SPAAC)。该试剂含有 NHS 酯官能团,用于将环辛炔连接到各种分子上。
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目录号 数量 价格 提前通知时间
34720 10 mg $80 现货
44720 25 mg $110 现货
54720 50 mg $135 现货
64720 100 mg $210 现货
94720 1 g $1000 现货
K4720 5 g $3570 现货
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DBCO-PEG6-NHS ester

A heterobifunctional linker with DBCO and NHS ester function groups flanking PEG6 (hexaethylene glycol).
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目录号 数量 价格 提前通知时间
3664-10mg 10 mg –   现货
3664-50mg 50 mg $247 现货
3664-100mg 100 mg $449 现货
3664-1g 1 g $3490 5 天
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DBCO-STP酯 (DBCO-STP ester)

一种活化酯用于蛋白质/抗体/肽的修饰,引入到无铜点击化学反应。
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目录号 数量 价格 提前通知时间
2584-5mg 5 mg –   现货
2584-10mg 10 mg $90 现货
2584-25mg 25 mg $180 现货
2584-100mg 100 mg $450 现货
2584-500mg 500 mg $1700 现货
2584-1g 1 g $3000 现货
2584-5g 5 g 请查询 现货
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Disuccinimidyl glutarate (DSG)

Homobifunctional crosslinker with two NHS ester groups at each end of a short 5-atom (7.7 angstrom) spacer.
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目录号 数量 价格 提前通知时间
4018-100mg 100 mg $95 现货
4018-1g 1 g $410 现货
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Exo-BCN-PNP

BCN-PNP carbonate is a tool to introduce BCN moety via carbamate linkage with primary amino groups of substrate.
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目录号 数量 价格 提前通知时间
4043-100mg 100 mg $280 现货
4043-500mg 500 mg $990 现货
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Hexynoic acid NHS ester

Hexynoic acid NHS ester for the labeling of biomolecules with alkyne group for copper-catalyzed click chemistry.
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目录号 数量 价格 提前通知时间
41720 25 mg $95 现货
51720 50 mg $180 现货
61720 100 mg $290 现货
91720 1 g 请查询 现货
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Hexynoic acid STP ester

Alkyne activated ester for the modification of amine groups. STP ester group is an excellent alternative to NHS ester functionality.
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目录号 数量 价格 提前通知时间
569-25mg 25 mg $95 现货
569-100mg 100 mg $185 现货
569-500mg 500 mg $850 现货
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戊烯酸STP酯 (Pentynoic acid STP ester)

一种活化酯,用于将炔基引入肽/蛋白质和链接反应。
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目录号 数量 价格 提前通知时间
30720 10 mg $110 现货
40720 25 mg $210 现货
50720 50 mg $410 现货
60720 100 mg $595 5 天
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TCO-PEG4-NHS ester (axial isomer)

A heterobifunctional linker with trans-cyclooctene and NHS ester groups flanking PEG4 (tetraethylene glycol) for labeling of antibodies, proteins, and other primary amine-containing biomolecules.
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目录号 数量 价格 提前通知时间
3056-10mg 10 mg $145 现货
3056-25mg 25 mg $225 现货
3056-100mg 100 mg $550 现货
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