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AF 568 DBCO

目录号 数量 价格 提前通知时间
1158F0 1 mg
$199.90
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2158F0 5 mg
$659.90
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4158F0 25 mg
$2099.00
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5158F0 50 mg
$2799.00
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6158F0 100 mg
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Dibenzocyclooctyne (DBCO, DBCO, ADIBO) is one of the most reactive cycloalkynes for copper-free click reaction (SPAAC, strain-promoted azide-alkyne cycloaddition). The rate of interaction of DBCO with azides is significantly higher than that of other cyclooctynes, as well as Cu-catalyzed click reaction (CuAAC). Unlike other cyclooctynes, DBCO does not interact with tetrazines, which makes it possible to use it in bioorthogonal reactions together with trans-cyclooctenes and tetrazines.

AF 568 is a bright, photostable, and hydrophilic fluorophore that emits in the orange channel. The absorption maximum is 572 nm. The emission maximum is 598 nm.

AF 568 DBCO allows fluorescent labeling of azide-containing biomolecules inside living cells and whole organisms without the negative effect of copper ions on them, and inanimate samples.

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General properties

Appearance: dark violet solid
Molecular weight: 1197.53
Molecular formula: C66H80N6O11S2
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. Avoid prolonged exposure to light.
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产品规格

Spectral properties

Excitation/absorption maximum, nm: 572
ε, L⋅mol−1⋅cm−1: 94238
Emission maximum, nm: 598
Fluorescence quantum yield: 0.912

产品引用

  1. Kofoed, C.; Erkalo, G.; Tay, N. E. S.; Ye, X.; Lin, Y.; Muir, T. W. Programmable Protein Ligation on Cell Surfaces. Nature, 2025, 645(8081), 793–800. doi: 10.1038/s41586-025-09287-2
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