Alkyne-PEG4-phosphoramidite
| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 2779-100mg | 100 mg | $390 | 现货 | |
| 2779-250mg | 250 mg |
$680
|
现货 | |
| 2779-1g | 1 g |
$1640
|
现货 | |
| 2779-5g | 5 g | 请查询 | 现货 |
Alkyne-PEG4-phosphoramidite is a tetraethylene glycol phosphoramidite with a terminal triple bond that can be used for the synthesis of various functionalized oligonucleotides. An alkyne fragment in the resulting molecules reacts in Click Chemistry reactions with azide-containing compounds in the presence of copper (I) salts to produce various oligonucleotide conjugates, such as those with dyes, peptides, or glycans. The yield of resulting compounds is rather high, their isolation and purification are often easier than those of molecules produced by the interaction of amino-modified oligonucleotides with activated esters such as those of dyes. Click Chemistry reactions are bioorthogonal because neither terminal alkyne nor azide functional groups usually are found in biomolecules.
A tetraethylene glycol linker in phosphoramidite gives it higher hydrophilic properties and reduces toxicity and immunogenicity of produced conjugates.
Recommendations for using the reagent:
Solvent: Acetonitrile.
Recommended condensation time: Standard, as for natural nucleoside phosphoramidites.
It is recommended to use standard deprotection conditions.
顾客还购买了这个产品
VdU (5-Vinyl-2'-deoxyuridine)
VdU is a synthetic analog of thymidine for studying de novo DNA synthesis and cell proliferation.AmdU（5-叠氮甲基-2'-脱氧尿苷) [AmdU (5-Azidomethyl-2'-deoxyuridine)]
叠氮甲基脱氧尿苷 (AmdU) 是一种含叠氮基的核苷，通过细胞内NDA聚合酶掺入到新生DNA中。通过这种方式连接到DNA 上的叠氮基团，随后可以通过铜催化或张力促进的点击反应，被炔烃或环炔烃修饰。endo-BCN CE-亚磷酰胺 (endo-BCN CE-phosphoramidite)
含 BCN 的亚磷酰胺，可用于寡核苷酸的合成及通过无铜点击反应对寡核苷酸的标记。
将此产品添加到购物车中并获得免费的快递服务
General properties
| Appearance: | colorless or yellow oil |
| Molecular weight: | 432.49 |
| CAS number: | 1682657-14-2 |
| Molecular formula: | C20H37N2O6P |
| IUPAC name: | 2-cyanoethyl (3,6,9,12-tetraoxapentadec-14-yn-1-yl) diisopropylphosphoramidite |
| Solubility: | good in acetonitrile and dichloromethane |
| Quality control: | NMR 1H and 31P, HPLC-MS (95%) |
| Storage conditions: | Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
| 安全数据表（MSDS）: | 下载 |
| 产品规格 |
Oligo synthesis details
| Diluent: | acetonitrile |
| Coupling conditions: | standard coupling, identical to normal nucleobases |
| Deprotection conditions: | identical to protected nucleobases |
您的购物车是空的
$ 
