此页面上的某些内容不提供英文版本，默认显示为当前可用的语言。

Thalidomide-O-PEG2-carboxylic acid

目录号	数量	价格	提前通知时间	购买此产品
4192-25mg	25 mg	$148	现货
4192-100mg	100 mg	$480	现货

批量询价

Found better price? Let us know and we will propose the way forward!

Thalidomide-containing building block with PEG2-linker and carboxylic group for convenient PROTAC molecule assembly via conjugation with amino-functionalized linkers and target protein ligands. The carboxylic acid functional group should be activated with peptide coupling reagents like PyBOP or carbodiimides like EDC to form a stable amide linkage with amines. PEG2 is a hydrophilic linker providing a good separation between the parts of the PROTAC molecule.

Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.

There are several types of E3 ligases that are practically suitable for such a purpose. Thalidomide is the ligand capable of recruiting Cereblon (CRBN) E3 ligase.

以ChemDraw格式下载

顾客还购买了这个产品

Thalidomide-carboxylic acid

Thalidomide-containing building block with carboxylic acid functionality for convenient PROTAC molecule assembly by attachment amino-functionalized linkers and ligands to thalidomide via 4-O-position.

将此产品添加到购物车中
并获得免费的快递服务

Thalidomide-O-PEG2-azide

Thalidomide-containing building block with PEG2-linker and azide function group for conjugation with alkyne-functionalized linkers and target protein ligands through click chemistry reactions.

将此产品添加到购物车中
并获得免费的快递服务

General properties

Appearance:	off-white solid
Molecular weight:	434.40
Molecular formula:	C₂₀H₂₂N₂O₉
Solubility:	in DMSO, DMF
Quality control:	NMR ¹H and HPLC-MS (95+%)
Storage conditions:	24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
安全数据表（MSDS）:	下载
	产品规格

Product is offered and sold for research purposes only. Product is not tested for safety and efficacy in food, drug, medical device, cosmetic, no express or implied authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, for humans or animals or for commercial purposes.

您的商品已添加. 查看您的购物车或者继续结账