Abasic phosphoramidite
目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
---|---|---|---|---|
3009-250mg | 250 mg | $179 | 现货 | |
3009-1g | 1 g | $358 | 现货 |
A compound for the phosphoramidite synthesis of oligonucleotides and the creation of the abasic step in the oligonucleotide sequence.
Cleavage of the N-glycosyl bond between a base and its 2-deoxyribose moiety in DNA generates an apurinic/apyrimidinic (so-called abasic) site. This phenomenon, which is referred to as depurination or depyrimidination occurs spontaneously under physiological conditions.
Abasic phosphoramidites are used in DNA and oligonucleotide synthesis. Abasic phosphoramidite imitates the loss of base pairing ability by a nucleotide. This modification of phosphoramidite is more stable than the natural abasic insert and can be used when examining DNA damage and repair.
Abasic phosphoramidite (dSpacer CE-Phosphoramidite) is a modification of 1',2'-dideoxyribose, contains a DMT protection of the hydroxymethyl group, and exhibits stability during synthesis and purification of oligonucleotides under standard conditions using AMA mixture, ammonium hydroxide / 40% methylamine (1:1).
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Phosphoramidite modifier for the synthesis of oligonucleotides containing alkyne modification in the middle of the chain.并获得免费的快递服务
TAMRA NHS 酯,5-异构体 (TAMRA NHS ester, 5-isomer)
胺反应性、活化的 TAMRA 染料 N-羟基琥珀酰亚胺酯,用于标记蛋白质、多肽和氨基寡核苷酸的胺基。纯5-异构体。General properties
Appearance: | white, off white to faint yellow viscous liquid |
Molecular weight: | 620.73 |
CAS number: | 129821-76-7 |
Molecular formula: | C35H45N2O6P |
Quality control: | NMR 1H and HPLC-MS (95+%) |
Storage conditions: | 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
安全数据表(MSDS): | 下载 |
产品规格 |
Oligo synthesis details
Diluent: | acetonitrile |
Coupling conditions: | standard coupling, identical to normal nucleobases |
Deprotection conditions: | identical to protected nucleobases |