Abasic phosphoramidite
目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
---|---|---|---|---|
3009-250mg | 250 mg | $179 | 现货 | |
3009-1g | 1 g | $358 | 现货 |
A compound for the phosphoramidite synthesis of oligonucleotides and the creation of the abasic step in the oligonucleotide sequence.
Cleavage of the N-glycosyl bond between a base and its 2-deoxyribose moiety in DNA generates an apurinic/apyrimidinic (so-called abasic) site. This phenomenon, which is referred to as depurination or depyrimidination occurs spontaneously under physiological conditions.
Abasic phosphoramidites are used in DNA and oligonucleotide synthesis. Abasic phosphoramidite imitates the loss of base pairing ability by a nucleotide. This modification of phosphoramidite is more stable than the natural abasic insert and can be used when examining DNA damage and repair.
Abasic phosphoramidite (dSpacer CE-Phosphoramidite) is a modification of 1',2'-dideoxyribose, contains a DMT protection of the hydroxymethyl group, and exhibits stability during synthesis and purification of oligonucleotides under standard conditions using AMA mixture, ammonium hydroxide / 40% methylamine (1:1).
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六乙二醇亚磷酰胺 (Hexaethylene glycol phosphoramidite)
间隔基亚磷酰胺 18(六乙二醇亚酰胺)为寡核苷酸合成提供一个长的亲水性连接基。TAMRA NHS ester, 6-isomer
NHS-ester of TAMRA dye for proteins, peptides, and modified oligonucleotides labeling via reaction with amino groups. Pure 6-isomer.FAM 亚磷酰胺,6-异构体 (FAM phosphoramidite, 6-isomer)
单一构体 6-FAM 亚磷酰胺,用于寡核苷酸的修饰。General properties
Appearance: | white, off white to faint yellow viscous liquid |
Molecular weight: | 620.73 |
CAS number: | 129821-76-7 |
Molecular formula: | C35H45N2O6P |
Quality control: | NMR 1H and HPLC-MS (95+%) |
Storage conditions: | 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
安全数据表(MSDS): | 下载 |
产品规格 |
Oligo synthesis details
Diluent: | acetonitrile |
Coupling conditions: | standard coupling, identical to normal nucleobases |
Deprotection conditions: | identical to protected nucleobases |
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