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Oxabiphor acid

目录号 数量 价格 提前通知时间
3755-10g 10 g 请查询 12 天
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Oxabiphor (Oxabifor) acid is a chelator for the lanthanide tetraphosphonate complexes synthesis. Oxabiphor (oxa-bis-ethylenenitrile tetra(methylene phosphonic acid); oxybis(ethylene)bis(nitrilobismethylene)tetrakisphosphonic acid) is useful for the radionuclides delivery due to complexation properties [1].

Supplied as a dihydrate and meets the quality requirements:

Quality criteria (method) Reference value
Authenticity (1H NMR) meets the requirements
Key product content (1H NMR) not less than 98 %
Acceptable impurity (1H NMR) 2-(2-Aminoethoxy)ethylamine – no more than 0.3 %
Residual solvents class 1,2 (1H NMR) visual absence of signals in the spectrum (less than 0.1 %)
Authenticity (31P NMR) meets the requirements
Acceptable impurity (31P NMR) Trisphosphonates – no more than 1.0 %
Acceptable impurity (31P NMR) Hydroxymethylphosphonic acid – no more than 0.5 %
Chloride ion content (Reverse precipitation titration) no more than 0.2 %
Chemical impurities (Atomic emission spectroscopy) no more than (ug/g): As – 50; Ba – 5; Be – 0,25; Bi – 5; Cd – 50; Cr – 7; Cu – 2,5; Fe – 15; Hg – 125; Mn – 0,5; Mo – 5; Ni – 5; Pb – 5; Sn – 5; Sb – 50; Te – 50; Zn – 125; Al – 50

[1] Maruk A. et al. Synthesis, Complexation Properties, and Evaluation of New Aminodiphosphonic Acids as Vector Molecules for 68Ga Radiopharmaceuticals. Molecules. 2021. 26(8):2357. doi:10.3390/molecules26082357

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General properties

Appearance: white powder
Molecular weight: 480.18
Molecular formula: C8H24N2O13P4
IUPAC name: 2-[7-Phosphono-6-(phosphonomethyl)-3-oxa-6-azaheptyl]-2-aza-1,3-propanediylbis(phosphonic acid)
Quality control: NMR 1H (98+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
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