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Thalidomide-O-PEG2-amine

胺类蛋白水解靶向嵌合体(PROTAC)

目录号	数量	价格	提前通知时间	购买此产品
4401-100mg	100 mg	$425	现货
4401-250mg	250 mg	$749	现货

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Thalidomide-containing building block with PEG2-linker and amino group, which can be conjugated to other functionalized linkers and target protein ligands.

The amino group is highly reactive and can undergo reactions with carboxylic acids, activated esters (NHS, STP, etc.), carbonyls (such as ketones and aldehydes), and more.

Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.

There are several types of E3 ligases that are practically suitable for such a purpose. Thalidomide is the ligand capable of recruiting Cereblon (CRBN) E3 ligase.

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沙利度胺-O-PEG2-叠氮化物 (Thalidomide-O-PEG2-azide)

含有沙利度胺的结构单元，具有 PEG2 连接体和叠氮官能团，可通过点击化学反应与炔基连接体和靶蛋白配体偶联。 …

沙利度胺-O-PEG2-羧酸 (Thalidomide-O-PEG2-carboxylic acid)

含有沙利度胺的结构单元，具有 PEG2 连接子和羧基，用于与氨基连接子和目标蛋白配体偶联。 …

General properties

Appearance:	white crystalline solid
Molecular weight:	441.86
CAS number:	1957236-10-0 (hydrochloride)
Molecular formula:	C₁₉H₂₄ClN₃O₇
Solubility:	DMF, DCM, methanol
Quality control:	NMR ¹H and HPLC-MS (95+%)
Storage conditions:	24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
安全数据表（MSDS）:	下载
	产品规格

This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.