LumiTracker® Mito TMRE

Cell viability and apoptosis 线粒体 Microscopy Flow cytometry

目录号	数量	价格	提前通知时间	购买此产品
2274-1mg	1 mg	–	现货
2274-25mg	25 mg	$190	现货

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TMRE 广泛用于标记活细胞中的线粒体，但不兼容固定后的细胞。这种亲脂性且带正电的染料快速渗透质膜，不与膜蛋白相互作用而形成聚集体。TMRE 由于其跨膜电位而选择性地积聚在活性线粒体中。

除了用于成像目的的线粒体染色之外，TMRE 还用于使用 Nernst 方程定量测量线粒体膜电位。该染料可作为研究线粒体功能变化和细胞活力对刺激或感兴趣的药物反应的工具。由凋亡、坏死或其他因素引起的线粒体去极化的特征是膜电位降低，并且与具有极化线粒体的完整细胞相比，其荧光减少表明。

TMRE 应用包括荧光显微镜、流式细胞术、微孔板测定。该染料的最大激发波长为 549 nm：它可以被蓝色（488 nm）或黄绿（561 nm）激光有效激发。可以在 PE 通道中检测到该染料的发射（最大波长为 574 nm）。

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Сell-permeant, cationic, orange-fluorescent dye for staining active mitochondria in living cells in a potential-dependent manner. The stain is compatible with aldehyde fixation.

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外观:
分子量:	514.96
CAS 编号:	115532-52-0
分子式:	C₂₆H₂₇N₂ClO₇
IUPAC 名称:	3,6-bis(dimethylamino)-9-(2-ethoxycarbonylphenyl)xanthylium perchlorate
溶解度:
质量控制:
储存条件:
安全数据表（MSDS）:	下载
	产品规格

激发/吸收极大值，纳米:	552
发射极大值，纳米:	575

产品引用

Pislyagin, E. A.; Tarbeeva, D. V.; Yurchenko, E. A.; Menchinskaya, E. S.; Gorpenchenko, T. Y.; Pokhilo, N. D.; Kalinovskiy, A. I.; Aminin, D. L.; Fedoreyev, S. A. Neuroprotective Activity of Oligomeric Stilbenes from Alpha Grape Stems in In Vitro Models of Parkinson’s Disease. International Journal of Molecular Sciences, 2025, 26(6), 2411. doi: 10.3390/ijms26062411
Mikheeva, A.M.; Bogomolov, M.A.; Gasca, V.A.; Sementsov, M.V.; Spirin, P.V.; Prassolov, V.S.; Lebedev, T.D. Improving the power of drug toxicity measurements by quantitative nuclei imaging. Cell Death Discovery, 2024, 10, 181. doi: 10.1038/s41420-024-01950-3
Menchinskaya, E. S.; Chingizova, E. A.; Pislyagin, E. A.; Yurchenko, E. A.; Klimovich, A. A.; Zelepuga, E. A.; Aminin, D. L.; Avilov, S. A.; Silchenko, A. S. Mechanisms of Action of Sea Cucumber Triterpene Glycosides Cucumarioside A0-1 and Djakonovioside A Against Human Triple-Negative Breast Cancer. Marine Drugs, 2024, 22(10), 474. doi: 10.3390/md22100474
Moiseeva, N.; Eroshenko, D.; Laletina, L.; Rybalkina, E.; Susova, O.; Karamysheva, A.; Tolmacheva, I.; Nazarov, M.; Grishko, V. The Molecular Mechanisms of Oleanane Aldehyde-β-Enone Cytotoxicity against Doxorubicin-Resistant Cancer Cells. Biology, 2023, 12(3), 415. doi: 10.3390/biology12030415