此页面上的某些内容不提供英文版本，默认显示为当前可用的语言。

FAM phosphoramidite, 5-isomer

FAM（荧光素）寡核苷酸合成亚磷酰胺

目录号	数量	价格	提前通知时间
2639-500mg	500 mg	–	现货
2639-1g	1 g	$190 $147	现货
2639-5g	5 g	$740 $629	现货
2639-10g	10 g	$1290 $970	现货
2639-50g	50 g	请查询	21 天
2639-100g	100 g	请查询	21 天

Found better price? Let us know and we will propose the way forward!

Standard fluorescein (FAM) phosphoramidite for 5'-terminal oligonucleotide labeling, high isomeric purity single isomer. This highly purified amidite reagent ensures excellent coupling results with various synthesizers.

Samples and special offers are available for oligo manufacturers. Contact us for bulk supplies of this reagent.

以ChemDraw格式下载

顾客还购买了这个产品

DMS(O)MT 氨基链接臂 C6

用于引入氨基的脒基。

Alkyne-PEG3-amine

Alkyne-PEG3-amine is a medium-length heterobifunctional linker for conjugation.

FAM CPG 500，6-异构体 (FAM CPG 500, 6-isomer)

用于合成含有 3'-荧光素 (FAM) 修饰的寡核苷酸的可控孔玻璃。

将此产品添加到购物车中
并获得免费的快递服务

General properties

Appearance:	off white solid
Molecular weight:	843.94
CAS number:	147566-42-5
Molecular formula:	C₄₆H₅₈N₃O₁₀P
Solubility:	Good solubility in acetonitrile and DCM
Quality control:	NMR ¹H and ³¹P, HPLC-MS (95+%), isomeric purity > 97%
Storage conditions:	Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
安全数据表（MSDS）:	下载
	产品规格

Spectral properties

Excitation/absorption maximum, nm:	492
ε, L⋅mol⁻¹⋅cm⁻¹:	72000
Emission maximum, nm:	517
Fluorescence quantum yield:	0.93
CF₂₆₀:	0.22
CF₂₈₀:	0.17

Oligo synthesis details

Diluent:	acetonitrile
Coupling conditions:	coupling time 10 min
Cleavage conditions:	ammonia, 2 h at room temperature
Deprotection conditions:	identical to protected nucleobases; when AMA is used, deblock with ammonia alone for 30 min, then add methylamine

产品引用

Zharkov, T. D.; Markov, O. V.; Zhukov, S. A.; Khodyreva, S. N.; Kupryushkin, M. S. Influence of Combinations of Lipophilic and Phosphate Backbone Modifications on Cellular Uptake of Modified Oligonucleotides. Molecules, 2024, 29(2), 452. doi: 10.3390/molecules29020452
Bauer, I.; Ilina, E.; Zharkov, T.; Grigorieva, E.; Chinak, O.; Kupryushkin, M.; Golyshev, V.; Mitin, D.; Chubarov, A.; Khodyreva, S.; Dmitrienko, E. Self-Penetrating Oligonucleotide Derivatives: Features of Self-Assembly and Interactions with Serum and Intracellular Proteins. Pharmaceutics, 2023, 15(12), 2779. doi: 10.3390/pharmaceutics15122779
Petrunina, N.A.; Lebedev, V.V.; Kirillova, Y.G.; Aralov, A..V.; Varizhuk, A.M.; Sardushkin, M.V. DNA Intercalated Motifs with Non-Nucleoside Inserts. Russian Journal of Bioorganic Chemistry, 2021, 47(6), 1341–1344. doi: 10.1134/S1068162021060212

This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.