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FAM phosphoramidite, 5-isomer
目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
---|---|---|---|---|
2639-500mg | 500 mg | – | 现货 | |
2639-1g | 1 g | $190 | 现货 | |
2639-5g | 5 g | $740 | 现货 | |
2639-10g | 10 g | $1290 | 现货 | |
2639-50g | 50 g | 请查询 | 21 天 | |
2639-100g | 100 g | 请查询 | 21 天 |
Standard fluorescein (FAM) phosphoramidite for 5'-terminal oligonucleotide labeling, high isomeric purity single isomer. This highly purified amidite reagent ensures excellent coupling results with various synthesizers.
Samples and special offers are available for oligo manufacturers. Contact us for bulk supplies of this reagent.
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DusQ 1 phosphoramidite
A black quencher dye phosphoramidite for the synthesis of oligonucleotide probes labeled with DusQ 1 quenchers at 5’-terminal. Useful for HEX, JOE, ROX, Cyanine3.
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炔基亚磷酰胺,5'-端 (Alkyne phosphoramidite, 5'-terminal)
炔基烃亚磷酰胺,用于合成可用于点击化学的寡核苷酸。JOE 亚磷酰胺,6-异构体 (JOE phosphoramidite, 6-isomer)
JOE 染料亚磷酰胺用于合成标记寡核苷酸。 JOE 吸收和发射最大值介于 FAM 和 TAMRA/ROX 染料的最大值之间。
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General properties
Appearance: | off white solid |
Molecular weight: | 843.94 |
CAS number: | 147566-42-5 |
Molecular formula: | C46H58N3O10P |
Solubility: | Good solubility in acetonitrile and DCM |
Quality control: | NMR 1H and 31P, HPLC-MS (95+%), isomeric purity > 97% |
Storage conditions: | Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. |
安全数据表(MSDS): | 下载 |
产品规格 |
Spectral properties
Excitation/absorption maximum, nm: | 492 |
ε, L⋅mol−1⋅cm−1: | 72000 |
Emission maximum, nm: | 517 |
Fluorescence quantum yield: | 0.93 |
CF260: | 0.22 |
CF280: | 0.17 |
Oligo synthesis details
Diluent: | acetonitrile |
Coupling conditions: | coupling time 10 min |
Cleavage conditions: | ammonia, 2 h at room temperature |
Deprotection conditions: | identical to protected nucleobases; when AMA is used, deblock with ammonia alone for 30 min, then add methylamine |
产品引用
- Zharkov, T. D.; Markov, O. V.; Zhukov, S. A.; Khodyreva, S. N.; Kupryushkin, M. S. Influence of Combinations of Lipophilic and Phosphate Backbone Modifications on Cellular Uptake of Modified Oligonucleotides. Molecules, 2024, 29(2), 452. doi: 10.3390/molecules29020452
- Bauer, I.; Ilina, E.; Zharkov, T.; Grigorieva, E.; Chinak, O.; Kupryushkin, M.; Golyshev, V.; Mitin, D.; Chubarov, A.; Khodyreva, S.; Dmitrienko, E. Self-Penetrating Oligonucleotide Derivatives: Features of Self-Assembly and Interactions with Serum and Intracellular Proteins. Pharmaceutics, 2023, 15(12), 2779. doi: 10.3390/pharmaceutics15122779
- Petrunina, N.A.; Lebedev, V.V.; Kirillova, Y.G.; Aralov, A..V.; Varizhuk, A.M.; Sardushkin, M.V. DNA Intercalated Motifs with Non-Nucleoside Inserts. Russian Journal of Bioorganic Chemistry, 2021, 47(6), 1341–1344. doi: 10.1134/S1068162021060212
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