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FAM phosphoramidite, 5-isomer

寡核苷酸合成 FAM（荧光素）亚磷酰胺

目录号	数量	价格	提前通知时间
2639-500mg / 置于8mL带隔垫小瓶的易溶冻干态	500 mg	–	现货
2639-1g / 置于20mL带隔垫小瓶的易溶冻干态	1 g	$190 $147	现货
2639-5g / 置于30mL带隔垫小瓶	5 g	$740 $629	现货
2639-10g / 置于30mL带隔垫小瓶	10 g	$1290 $970	现货
2639-50g	50 g	请查询	21 天
2639-100g	100 g	请查询	21 天

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Standard fluorescein (FAM) phosphoramidite for 5'-terminal oligonucleotide labeling, high isomeric purity single isomer. This highly purified amidite reagent ensures excellent coupling results with various synthesizers.

Samples and special offers are available for oligo manufacturers. Contact us for bulk supplies of this reagent.

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DusQ® 3 CPG 500

DusQ® 3 is a dark quencher for far red and near infrared dyes like Cyanine5.5. This is a controlled pore glass solid support for the synthesis of oligonucleotides with the quencher attached to 3′-terminus.

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生物素亚磷酰胺（羟基脯氨醇） [Biotin phosphoramidite (hydroxyprolinol)]

生物素亚磷酰胺用于合成生物素化的寡核苷酸。含有二甲氧基三苯甲基基团。

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Cyanine3叠氮化物 (Cyanine3 azide)

用于 сlick сhemistry 的 Cyanine3 荧光染料的叠氮衍生物。

General properties

Appearance:	off white solid
Molecular weight:	843.94
CAS number:	147566-42-5
Molecular formula:	C₄₆H₅₈N₃O₁₀P
Solubility:	Good solubility in acetonitrile and DCM
Quality control:	NMR ¹H and ³¹P, HPLC-MS (95+%), isomeric purity > 97%
Storage conditions:	Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
安全数据表（MSDS）:	下载
	产品规格

Spectral properties

Excitation/absorption maximum, nm:	492
ε, L⋅mol⁻¹⋅cm⁻¹:	72000
Emission maximum, nm:	517
Fluorescence quantum yield:	0.93
CF₂₆₀:	0.22
CF₂₈₀:	0.17

Oligo synthesis details

Diluent:	acetonitrile
Coupling conditions:	coupling time 10 min
Cleavage conditions:	ammonia, 2 h at room temperature
Deprotection conditions:	identical to protected nucleobases; when AMA is used, deblock with ammonia alone for 30 min, then add methylamine

产品引用

Zharkov, T. D.; Markov, O. V.; Zhukov, S. A.; Khodyreva, S. N.; Kupryushkin, M. S. Influence of Combinations of Lipophilic and Phosphate Backbone Modifications on Cellular Uptake of Modified Oligonucleotides. Molecules, 2024, 29(2), 452. doi: 10.3390/molecules29020452
Bauer, I.; Ilina, E.; Zharkov, T.; Grigorieva, E.; Chinak, O.; Kupryushkin, M.; Golyshev, V.; Mitin, D.; Chubarov, A.; Khodyreva, S.; Dmitrienko, E. Self-Penetrating Oligonucleotide Derivatives: Features of Self-Assembly and Interactions with Serum and Intracellular Proteins. Pharmaceutics, 2023, 15(12), 2779. doi: 10.3390/pharmaceutics15122779
Petrunina, N.A.; Lebedev, V.V.; Kirillova, Y.G.; Aralov, A..V.; Varizhuk, A.M.; Sardushkin, M.V. DNA Intercalated Motifs with Non-Nucleoside Inserts. Russian Journal of Bioorganic Chemistry, 2021, 47(6), 1341–1344. doi: 10.1134/S1068162021060212

This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.