Abasic phosphoramidite
目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
---|---|---|---|---|
3009-250mg | 250 mg | $179 | 现货 | |
3009-1g | 1 g | $358 | 现货 |
A compound for the phosphoramidite synthesis of oligonucleotides and the creation of the abasic step in the oligonucleotide sequence.
Cleavage of the N-glycosyl bond between a base and its 2-deoxyribose moiety in DNA generates an apurinic/apyrimidinic (so-called abasic) site. This phenomenon, which is referred to as depurination or depyrimidination occurs spontaneously under physiological conditions.
Abasic phosphoramidites are used in DNA and oligonucleotide synthesis. Abasic phosphoramidite imitates the loss of base pairing ability by a nucleotide. This modification of phosphoramidite is more stable than the natural abasic insert and can be used when examining DNA damage and repair.
Abasic phosphoramidite (dSpacer CE-Phosphoramidite) is a modification of 1',2'-dideoxyribose, contains a DMT protection of the hydroxymethyl group, and exhibits stability during synthesis and purification of oligonucleotides under standard conditions using AMA mixture, ammonium hydroxide / 40% methylamine (1:1).
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抗坏血酸 (Ascorbic acid)
抗坏血酸是一种还原剂,可将铜 (II) 转化为用于催化点击反应的一价形式。FAM 亚磷酰胺,6-异构体 (FAM phosphoramidite, 6-isomer)
单一构体 6-FAM 亚磷酰胺,用于寡核苷酸的修饰。Alkyne dT phosphoramidite
Phosphoramidite modifier for synthesizing oligonucleotides containing alkyne modification in the middle of the chain.并获得免费的快递服务
General properties
Appearance: | white, off white to faint yellow viscous liquid |
Molecular weight: | 620.73 |
CAS number: | 129821-76-7 |
Molecular formula: | C35H45N2O6P |
Quality control: | NMR 1H and HPLC-MS (95+%) |
Storage conditions: | 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
安全数据表(MSDS): | 下载 |
产品规格 |
Oligo synthesis details
Diluent: | acetonitrile |
Coupling conditions: | standard coupling, identical to normal nucleobases |
Deprotection conditions: | identical to protected nucleobases |