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VHL Ligand 1 dihydrochloride
| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 4065-250mg | 250 mg | $175 | 现货 | |
| 4065-500mg | 500 mg | $258 | 现货 | |
| 4065-1g | 1 g |
$469
|
现货 |
Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.
VHL Ligand 1 (VH032-NH2, (S,R,S)-AHPC) is a synthetic E3 ligase ligand that is used as a building block for the synthesis of proteolysis-targeting chimera (PROTAC) molecules.
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沙利度胺-羧酸 (Thalidomide-carboxylic acid)
含有沙利度胺的结构单元，具有羧酸官能团，通过 4-O-位将功能化氨基接头和配体连接到沙利度胺上，从而方便地组装 PROTAC 分子。Thalidomide-O-PEG2-amine
Thalidomide-containing building block with PEG2-linker and amino group for conjugation with other functionalized linkers and target protein ligands.
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(S,R,S)-AHPC-PEG2-C2-azide
Degrader building block containing an E3 ligase ligand with linker and azide group, which can be conjugated to alkyne-functionalized linkers and target protein ligands through click chemistry reactions.General properties
| Appearance: | yellow-brown powder |
| Molecular weight: | 503.50 |
| CAS number: | 1448189-80-7 (monohydrochloride) |
| Molecular formula: | C22H32Cl2N4O3S |
| IUPAC name: | (4R)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide, dihydrochloride |
| Solubility: | methanol, DCM, DMF, DMSO |
| Quality control: | NMR 1H and HPLC-MS (95+%) |
| Storage conditions: | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
| 安全数据表（MSDS）: | 下载 |
| 产品规格 |
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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