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(S,R,S)-AHPC-PEG2-C2-azide

叠氮化物 PROTAC Click chemistry Copper-free click chemistry
目录号 数量 价格 提前通知时间
4530-25mg 25 mg $189 现货
4530-100mg 100 mg $529 现货
4530-500mg 500 mg $1598 现货
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Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.

(S,R,S)-AHPC-C2-azide is a protein degrader building block for the synthesis of molecules for targeted protein degradation and PROTAC technologies. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEG2-C2 crosslinker with an azide function group, which can be conjugated to alkyne-functionalized linkers and target protein ligands through click chemistry reactions.

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沙利度胺-O-PEG2-叠氮化物 (Thalidomide-O-PEG2-azide)

含有沙利度胺的结构单元，具有 PEG2 连接体和叠氮官能团，可通过点击化学反应与炔基连接体和靶蛋白配体偶联。

沙利度胺-O-PEG2-羧酸 (Thalidomide-O-PEG2-carboxylic acid)

含有沙利度胺的结构单元，具有 PEG2 连接子和羧基，用于与氨基连接子和目标蛋白配体偶联。
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沙利度胺-羧酸 (Thalidomide-carboxylic acid)

含有沙利度胺的结构单元，具有羧酸官能团，通过 4-O-位将功能化氨基接头和配体连接到沙利度胺上，从而方便地组装 PROTAC 分子。

General properties

Appearance: yellow glassy oil
Molecular weight: 615.75
CAS number: 2597167-22-9
Molecular formula: C29H41N7O6S
Solubility: methanol, ethyl acetate, DCM, THF, DMF, DMSO
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
安全数据表（MSDS）: 下载
产品规格
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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