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DDTT Sulfurizing Reagent

寡核苷酸合成

目录号	数量	价格	提前通知时间
3179-1g	1 g	–	现货
3179-5g	5 g	$245	现货
3179-25g	25 g	$1150	现货
3179-50g	50 g	$1800	现货
3179-100g	100 g	请查询	现货

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现货商品将于以下日期发货 03/26/2025

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DDTT is a sulfurizing reagent used to prepare phosphorothioate linkages, which increase the stability and nuclease resistance of nucleic acids, especially of RNA. It is suitable for automated synthesizers employing standard phosphoramidites for a large-scale synthesis of oligonucleotides.

DDTT demonstrates faster kinetics and higher stability in solution, compared to other sulfurizing reagents such as tetraethylthiuram disulfide (TETD) and Beaucage reagent, respectively. DDTT is commonly applied as a 0.05 M or 0.1 M solution in pyridine/acetonitrile and has a lifetime of up to 6 months.

Usage

Coupling: Sulfurization step must come before capping step. The optimum sulfurizing time for DDTT Sulfurizing Reagent, 0.05 M solution in pyridine/acetonitrile: 1 min for DNA or 6 min for RNA.

Deprotection: standard conditions.

以ChemDraw格式下载

General properties

Appearance:	lemon yellow crystals
Molecular weight:	205.33
CAS number:	1192027-04-5
Molecular formula:	C₅H₇N₃S₃
Quality control:	NMR ¹H and HPLC-MS (95+%)
Storage conditions:	24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
安全数据表（MSDS）:	下载
	产品规格