此页面上的某些内容不提供英文版本，默认显示为当前可用的语言。

LumiTracker® Mito JC-1

Mitochondria Cell viability and apoptosis Microscopy Flow cytometry Membrane potential measurement
目录号 数量 价格 提前通知时间
2275-50ug 50 ug –   现货
2275-1mg 1 mg $110 现货
2275-5mg 5 mg $150 现货
样品请求
Found better price? Let us know and we will propose the way forward!

JC-1 is a cationic carbocyanine dye that accumulates in the mitochondria of live cells in a potential-dependent manner.

The dye exists as a green-fluorescent monomer at depolarized membranes and low concentrations. At higher concentrations (aqueous solutions above 0.1 µM) and hyperpolarized membranes, the dye forms J-aggregates that exhibit an emission at the orange channel.

Healthy cells have high mitochondrial membrane potential, and the decrease of mitochondrial membrane potential is a marker of the early stage of apoptosis. All this allows the use of changes in the orange/green fluorescence ratio of JC-1 to determine healthy vs. depolarized mitochondria. The orange/green fluorescence ratio of JC-1 depends only on the mitochondrial membrane potential and not on other factors such as the size, shape, and density of mitochondria.

以ChemDraw格式下载

染色示例

顾客还购买了这个产品

LUCS® 13, green fluorescent nucleic acid stain

LUCS 13 is a cell-permeant green fluorescent nucleic acid stain that exhibits bright, green fluorescence upon binding to nucleic acids.

TO-TAP-1，绿色荧光核酸染料 (TO-TAP-1, green fluorescent nucleic acid stain)

TO-TAP-1是一种不渗透细胞的绿色荧光核酸染料。 TO-TAP-1的化学性质与 TO-PRO®-1 相同。

6-Carboxy-H2DCFDA (6-carboxy-2',7'-dichlorodihydrofluorescein)

A reagent for detecting reactive oxygen species (ROS) in living cells. This carboxylated H2DCFDA analog has two additional negative charges that impede its leakage out of the cell.

General properties

Appearance: red-purple solid
Molecular weight: 652.24
CAS number: 47729-63-5; 3520-43-2
Molecular formula: C25H27Cl4IN4
IUPAC name: 1H-Benzimidazolium, 5,6-dichloro-2-[3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)-1-propen-1-yl]-1,3-diethyl-, iodide
Solubility: good in DMSO
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
安全数据表（MSDS）: 下载
产品规格

产品引用

  1. Katkova, S.A.; Bunev, A.S.; Gasanov, R.E.; Khochenkov, D.A.; Kulsha, A.V.; Ivashkevich, O.A.; Serebryanskaya, T.V.; Kinzhalov, M. Metal‐(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple‐Negative Breast Cancer. Chem. Eur. J., 2024, e202400101. doi: 10.1002/chem.202400101
  2. Kirsanov, R.S.; Khailova, L.S.; Rokitskaya, T.I.; Lyamzaev, K.G.; Panteleeva, A.A.; Nazarov, P.A.; Firsov, A.M.; Iaubasarova, I.R.; Korshunova, G.A.; Kotova, E.A.; Antonenko, Y.N. Synthesis of Triphenylphosphonium-Linked Derivative of 3,5-Di tert -butyl-4-hydroxybenzylidene-malononitrile (SF6847) via Knoevenagel Reaction Yields an Effective Mitochondria-Targeted Protonophoric Uncoupler. ACS Omega, 2024, 9(10), 11551-11561. doi: 10.1021/acsomega.3c08621
  3. Menchinskaya, E. S.; Chingizova, E. A.; Pislyagin, E. A.; Yurchenko, E. A.; Klimovich, A. A.; Zelepuga, E. A.; Aminin, D. L.; Avilov, S. A.; Silchenko, A. S. Mechanisms of Action of Sea Cucumber Triterpene Glycosides Cucumarioside A0-1 and Djakonovioside A Against Human Triple-Negative Breast Cancer. Marine Drugs, 2024, 22(10), 474. doi: 10.3390/md22100474
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
您的商品已添加. 查看您的 购物车 或者 继续结账
商品数量不正确.