LumiTracker® Mito JC-1
| 目录号 | 数量 | 价格 | 提前通知时间 | 购买此产品 |
|---|---|---|---|---|
| 2275-50ug | 50 ug | – | 现货 | |
| 2275-1mg | 1 mg | $110 | 现货 | |
| 2275-5mg | 5 mg | $150 | 现货 |
JC-1 is a cationic carbocyanine dye that accumulates in the mitochondria of live cells in a potential-dependent manner.
The dye exists as a green-fluorescent monomer at depolarized membranes and low concentrations. At higher concentrations (aqueous solutions above 0.1 µM) and hyperpolarized membranes, the dye forms J-aggregates that exhibit an emission at the orange channel.
Healthy cells have high mitochondrial membrane potential, and the decrease of mitochondrial membrane potential is a marker of the early stage of apoptosis. All this allows the use of changes in the orange/green fluorescence ratio of JC-1 to determine healthy vs. depolarized mitochondria. The orange/green fluorescence ratio of JC-1 depends only on the mitochondrial membrane potential and not on other factors such as the size, shape, and density of mitochondria.
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Cyanine5.5 NHS酯 (Cyanine5.5 NHS ester)
Cyanine5.5 NHS 是一种远红/近红外胺反应性染料。
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DMF（二甲基甲酰胺）, 标签级 (DMF (dimethylformamide), labeling grade)
即用型高纯度、无胺溶剂，用于 NHS 酯标记。Cyanine3.5 NHS ester (Cyanine3.5 NHS酯)
Cyanine3.5染料NHS酯的衍生物。
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General properties
| Appearance: | red-purple solid |
| Molecular weight: | 652.24 |
| CAS number: | 47729-63-5; 3520-43-2 |
| Molecular formula: | C25H27Cl4IN4 |
| IUPAC name: | 1H-Benzimidazolium, 5,6-dichloro-2-[3-(5,6-dichloro-1,3-diethyl-1,3-dihydro-2H-benzimidazol-2-ylidene)-1-propen-1-yl]-1,3-diethyl-, iodide |
| Solubility: | good in DMSO |
| Quality control: | NMR 1H and HPLC-MS (95+%) |
| Storage conditions: | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
| 安全数据表（MSDS）: | 下载 |
| 产品规格 |
产品引用
- Katkova, S.A.; Bunev, A.S.; Gasanov, R.E.; Khochenkov, D.A.; Kulsha, A.V.; Ivashkevich, O.A.; Serebryanskaya, T.V.; Kinzhalov, M. Metal‐(Acyclic Diaminocarbene) Complexes Demonstrate Nanomolar Antiproliferative Activity against Triple‐Negative Breast Cancer. Chem. Eur. J., 2024, e202400101. doi: 10.1002/chem.202400101
- Kirsanov, R.S.; Khailova, L.S.; Rokitskaya, T.I.; Lyamzaev, K.G.; Panteleeva, A.A.; Nazarov, P.A.; Firsov, A.M.; Iaubasarova, I.R.; Korshunova, G.A.; Kotova, E.A.; Antonenko, Y.N. Synthesis of Triphenylphosphonium-Linked Derivative of 3,5-Di tert -butyl-4-hydroxybenzylidene-malononitrile (SF6847) via Knoevenagel Reaction Yields an Effective Mitochondria-Targeted Protonophoric Uncoupler. ACS Omega, 2024, 9(10), 11551-11561. doi: 10.1021/acsomega.3c08621
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